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Solubiliy of Sodium Cefotaxime in Aqueous 2-Propanol ...

Oct 19, 2006· Using a laser monitoring observation technique, the solubilities of sodium cefotaxime (A) in binary water (B) + 2-propanol (C) solvent mixtures were determined by the synthetic method from 278.15 K to 308.15 K and in the solvent composition ( ) range from 0.025 to 1.000. The results of these measurements were correlated by the combined nearly ideal binary solvent (CNIBS)/Redlich−Kister ...

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Cefotaxime sodium - wikidoc

There is limited information regarding Cefotaxime sodium Clinical Studies in the drug label. How Supplied. Sterile Cefotaxime for Injection, USP, is a dry off-white to pale yellow crystalline powder supplied in vials and bottles containing cefotaxime sodium as follows: 500 mg cefotaxime (free acid equivalent) vials in packages of 10 (NDC 0143 ...

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cefotaxime sodium | CAS#:6 | Chemsrc

Jan 26, 2021· Chemsrc provides cefotaxime sodium(CAS#:6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of …

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Cefotaxime: Uses, Interactions, Mechanism of Action ...

Cefotaxime may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level. Sodium citrate The therapeutic efficacy of Sodium citrate can be decreased when used in combination with Cefotaxime.

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Cefotaxime sodium, powder for injection, equivalent to ...

Cefotaxime is a white to slightly yellowish powder, which, when dissolved in Water for Injections B.P., forms a straw coloured solution given by intravenous or intramuscular administration. Each Cefotaxime 500 mg vial contains sterile cefotaxime sodium equivalent to cefotaxime 500 mg.

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CAS No : 6 | Product Name : Cefotaxime Sodium ...

Buy highly pure Cefotaxime Sodium - Impurity D, CAS No : 6, Mol.Formula : C16H17N5O7S2, Mol.Weight : 455.47, from Pharmaffiliates. Login as registered user ...

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Cefotaxime Sodium

Add 25 mg of sodium carbonate, mix, and allow to stand at room temperature for 10 minutes, with occasional swirling. Add 3 drops of glacial acetic acid and 1 mL of Standard preparation, and mix. Assay preparation— Transfer about 40 mg of Cefotaxime Sodium, accurately weighed, to a 50-mL volumetric flask, add Solution A to dissolve it, dilute ...

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Substance Name: Cefotaxime sodium [USAN:USP:JAN]

6 - AZZMGZXNTDTSME-JUZDKLSSSA-M - Cefotaxime sodium [USAN:USP:JAN] - Similar structures search, synonyms, formulas, resource links, and other chemical information.

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Cefotaxime sodium: A new and efficient corrosion inhibitor ...

May 01, 2009· High inhibition efficiency of cefotaxime sodium is attributed to presence of free NH 2 group which gets strongly protonated in hydrochloric acid solution. Week protonation of pyridine N of cefatrexyl gives low inhibition efficiency. 4. ConclusionThe inhibition efficiency of cefotaxime sodium increases with increase in the inhibitor concentration.

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CLAFORAN Sterile (cefotaxime for injection, USP) and ...

cefotaxime sodium to test the susceptibility of microorganisms to cefotaxime sodium. Reports from the laboratory providing results of the standard single-disk susceptibility test using a 30 mcg cefotaxime sodium disk should be interpreted according to the following criteria: When testing organisms. a. other than . Haemophilus. spp., Neisseria ...

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EP0799232A1 - Production of cefotaxime and new sodium ...

cefotaxime compound acetone sodium salt Prior art date Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Ceased Application number EP95942724A Other languages German (de) French (fr) Inventor ...

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Study on Cefotaxime and Sulbactam Sodium for Injection (2 ...

Aug 31, 2011· Cefotaxime is a third-generation cephalosporins.Cefotaxime sodium and sulbactam sodium for injection (2:1)plays a therapeutic role by the former inhibiting bacterial cell wall synthesis by irreversible competitive inhibition of β-lactamase.The antimicrobial effect of cefotaxime can be enhanced by the two combined.The compound specifically aims to the mechanism of bacterial resistance ...

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IMPORTANT PRESCRIBING INFORMATION Temporary …

Cefotaxime sodium for Injection, BP in the dry state should be stored at room temperature (15-25°C), protected from light and heat. The dry powder as well as solutions tend to darken, depending ...

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Cefotaxime Sodium | CAS#6 | Cephalosporin ...

Cefotaxime Sodium is the sodium salt form of cefotaxime, a beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Cefotaxime sodium binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linking of peptidoglycan chains necessary for bacterial cell wall ...

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DailyMed - CEFOTAXIME injection, powder, for solution

Nov 26, 2019· Sterile Cefotaxime for injection, USP is a dry off-white to pale yellow crystalline powder supplied in vials containing cefotaxime sodium as follows: 500 mg cefotaxime (free acid equivalent) in vials in packages of: Package of 1 NDC 64679-947-01. Package of 10 NDC 64679-947-02

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DailyMed - CEFOTAXIME injection, powder, for solution

Oct 19, 2010· Sterile Cefotaxime for injection, USP is a dry off-white to pale yellow crystalline powder supplied in vials containing cefotaxime sodium as follows: 500 mg cefotaxime (free acid equivalent) in vial. Package of 1 NDC 64679-947-01 Package of 10 NDC 64679-947-02 1 g cefotaxime (free acid equivalent) in vial.

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Cefotaxime - Wikipedia

Cefotaxime is an antibiotic used to treat a number of bacterial infections. Specifically it is used to treat joint infections, pelvic inflammatory disease, meningitis, pneumonia, urinary tract infections, sepsis, gonorrhea, and cellulitis. It is given either by injection into a vein or muscle.. Common side effects include nausea, allergic reactions, and inflammation at the site of injection.

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Cefotaxime - an overview | ScienceDirect Topics

Cefotaxime has a broad spectrum of antibicrobial use. It acts bactericidally. It is highly active with respect to Gram-negative microorganisms (E. coli, Citrobacter, Proteus mirabilis, P. indole, Providencia, Klebsiella, Serratia), and a few strains of Pseudomonas, H. influenzae that are resistant to other antibiotics.Cefotaxime is less active with respect to streptococci, pneumococci ...

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CN1394863A - Method for synthesizing cefotaxime sodium ...

The present invention discloses a method for synthesizing cefotaxime sodium, and said method includes the following steps: placing 7-amino cephaloalkyl acid (7-ACA) and benzothiazol active ester (MEAM) in organic solvent, using triethylamine as condensation agent, under the catalysis of phase transfer catalyst making them produce condensation reaction to obtain cefotaxime acid, and making …

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Quality of cefotaxime sodium preparations

Cefotaxime sodium (CAS 6) is a semisynthetic cephalosporin derivative belonging to the third-generation cephalosporins. Owing to its broad antibacterial activity and its high resistance to beta-lactamases it can be used for a large variety of infections. In the present study the quality sta …

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Cefotaxime Sodium EP Impurity F . 17

Investigation on the Spherical Crystallization Process of Cefotaxime Sodium Haitao Zhang, Ying Chen, Jingkang Wang,, and Junbo Gong Ind. Eng. Chem. Res. 2010, 49, 1402–1411 Identification and characterization of new impurity in Cefotaxime Sodium drug substance

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Cefotaxime Sodium, chemical structure, molecular formula ...

in which C is the concentration,in mg per mL,of USP Cefotaxime Sodium RS in the Standard preparation, P is the designated content,in µg per mg,of cefotaxime (C 16 H 17 N 5 O 7 S 2)in USP Cefotaxime Sodium RS, W is the weight,in mg,of Cefotaxime Sodium taken to prepare the Assay preparation,and r U and r S are the cefotaxime peak area responses ...

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Synthesis and effect of pegylation on citric acid ...

Synthesis and effect of pegylation on citric acid dendritic nano architectures anchored with cefotaxime sodium J Photochem Photobiol B. 2019 Dec;201:111683. doi: 10.1016/j.jphotobiol.2019.111683. Epub 2019 Nov 6. Authors Viswanath Valikala 1 ...

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Chemistry of cefotaxime | Journal of Antimicrobial ...

Jan 01, 1980· This problem has been solved by building the aminothiazole ring on to an existing syn-methoxy-imino acetic acid derivative and condensing the resulting pure syn-methoxy-iminoaminothiazole acetic acid with 7-amino cephalosporanic acid. The stable crystalline sodium salt, cefotaxime, is readily obtained by adding the free acid to an aqueous ...

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Cefotaxime

Cefotaxime. Cefotaxime. CLINICAL USE. Antibacterial agent. DOSE IN NORMAL RENAL FUNCTION. Mild infection: 1 g every 12 hours. Moderate infection: 1 g every 8 hours. Severe infection: 2 g every 6 hours. Life-threatening infection: up to 12 g daily in 3–4 divided doses.

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Cefotaxime (Cefotaxima acid) | CAS 6 | AbMole ...

Cefotaxime is an inhibitor of penicillin binding protein. Cefotaxime exhibits an MIC of 0.0625 mg/L for V. vulnificus CMCP6. The combination of ciprofloxacin and cefotaxime is more effective in clearing V. vulnificus in vivo than previously used regimens.

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Process for the production of cefotaxime sodium - Justia

Jul 17, 2006· Cefotaxime acid is converted to cefotaxime sodium (Formula VII); in a mixture of methanol and ethyl acetate in presence of triethylamine and sodium-2-ethylhexanonate. The product is precipitated by addition of excess ethyl acetate which on filtration provides final …

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Cefotaxime Sodium, CulturePure®-cell culture-TOKU-E

Cefotaxime Sodium is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients.

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Global 7-Aminocephalosporanic Acid (7-ACA) Market Research ...

From a global perspective this report represents overall Aminocephalosporanic Acid ACA market size by analyzing historical data and future prospect. Length: 92 pages, Tables & Figures: 104, Product: 7-Aminocephalosporanic Acid (7-ACA), Product-Type: Cefazolin Sodium, Cefotaxime Sodium, Ceftriaxone Sodium, Cefoperazone Sodium, Ceftazime Sodium, Cefuroxime Sodium, Application: …

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Cefotaxime Sodium-impurities | Pharmaffiliates

Cefotaxime Sodium is used to treat a wide variety of bacterial infections. It is an antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram positive and Gram negative bacteria.. Reference standards of Cefotaxime Sodium API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below

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Cefotaxime sodium salt | Molecular Biology | Molecular ...

Buy and get information for Cefotaxime sodium salt, MB134, 6, Molecular Biology, Molecular Biology Chemicals

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Degradation kinetics in aqueous solution of cefotaxime ...

The degradation kinetics of a 3‐acetoxymethylcephalosporin, cefotaxime sodium salt, in aqueous solution investigated by HPLC under different conditions (pH, ionic strength, temperature) and using different buffers. The scheme of degradation involves a cleavage of the β‐lactam nucleus and the deacetylation of the side chain.

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Spectrophotometric estimation of cefotaxime and ...

The reaction is based on the reduction of phosphomolybdotungstic acid, the FC reagent, by cefotaxime and ceftriaxone in presence of 20% sodium carbonate solution, thereby producing reduced species having characteristic blue colour with maximum absorption at 752 nm and 750 nm respectively.

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Cefotaxime Acid | CAS No- 6 | Simson Pharma Limited

Buy Cefotaxime Acid (CAS No- 6) online from SimSon Pharma, a global manufacturer & supplier of pharmaceutical intermediates. [email protected] +91-8767930669

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(Z)-Cefotaxime | C16H17N5O7S2 | ChemSpider

Cefotaxime is an antibiotic used to treat a number of bacterial infections . Common side effects include nausea, allergic reactions, and inflammation at the site of injection. It is in the third-generation cephalosporin family of medications and works by interfering with the bacteria's cell wall.

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Cefotaxime Acid(Cefotaxime) – Welcome to AOZEAL.COM

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